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(2020) A System Biology Approach to Discern the Native Biochemical Function of Hg Methylation Proteins in Desulfovibrio desulfuricans ND132

Gionfriddo C, Wymore A, Podar M, Gilmour C, Soren A, Wilpiszeski R & Elias D


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Submitted by Rachel Strickman on Monday 22nd June 19:08
Thank you for this exciting project. I was interested to note that the differences in central metabolism only appeared in fermentative and sulfate reducing conditions, ie, conditions that occur only in anoxic environments in nature. Do you think it is possible that the environmental correlation between anoxia and Hg methylation is the result of metabolic up-regulation of the hgcAB pathway (and whatever it is doing for the carbon metabolism of the cell), rather than an ecological limitation of the hg methylators to anoxic environments or microsites? That is, perhaps hgcAB is only "turned on" in these conditions, rather than methylators only being present in these conditions? thank you again, Rachel Strickman

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